P.024 Pain in monogenic Parkinson’s Disease

Background: Pain is one of the most bothersome symptoms reported in Parkinson’s disease (PD), yet its underlying pathophysiological mechanisms are not well understood. Its prevalence and effects on quality life patients with monogenic forms PD have been systematically explored. Methods: Comprehensive literature review exploring association between ( SNCA , PRKN PINK1 DJ1 LRRK2 ) pain. We included pain ATP13A2, VPS35 GBA1 mutation carriers. After initial screening, sixty-five relevant articles were identified. Studies’ design, sample sizes, outcome measures highly heterogeneous. Results: Our suggests that some causes show a higher specific subtypes. While painful foot dystonia more frequently carriers, last ones also describe frequent lower back mostly. general commonly carriers followed by mutations. as an symptom severe described -PD patients. There limited insufficient evidence to report ATP13A2 Conclusions: Linking genetic profiles outcomes may meaningful clinical impact, facilitating individualized treatment for PD.